The Pelger-huuet Anomaly and Megaloblastic Anemia.

By S. ARDEMAN, I. CIIANARIN AND A. \V. FRANKLAND T HE Pelger-Huet anomaly of Ieukocytcs is characterized by the ence of tii oval, indented or bibbed ( “pincc-nez” ) nucleus in the neutrophil polymorphonuclear leukocytes which replaces the normal nuclear segmentation of these cells ( Pelger’ ) . It is inherited as an autosomal dominant characteristic ( Hu#{235}t2 ) , the incidence being 1 in 6000 of the population ( DavidSOfl:i ) . By contrast, rnegaloblastic anemia is characterized by an increase in the number of lobes in the neutrophil nucleus. The combination of addisonian pernicious anemia in a family with the Pelger-Hu#{235}t anomaly enabled us to observe the effect of the megalol)lastic process on the morphology of the cells exhibiting the Pelger-Hu#{235}t trait. This paper reports our observations.